Pet Health

Cushing’s Disease In Dogs: Symptoms, Causes & Treatment

Discover the symptoms, causes, and effective treatment options for Cushing's Disease in dogs. Empower your pet's health with our comprehensive guide!
Author: Veterinary Team
Dial A Vet
Updated
June 6, 2025
|
Published
June 6, 2025
Golden retriever showing signs of Cushing's disease, with symptoms like increased thirst and hair loss in a veterinary setting.

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It’s always distressing when your dog isn’t feeling their best, especially when symptoms don’t have an obvious cause. If you’ve noticed changes in your dog’s energy, appetite, or appearance, Cushing’s disease might be a condition to consider. This common endocrine disorder primarily affects middle-aged and senior dogs, and while it can sound overwhelming, understanding the symptoms, causes, and treatment options can help you feel more in control and confident about your pet’s care.

⚠️ What to Watch For

Cushing’s disease, also known as hyperadrenocorticism, happens when a dog’s body produces too much cortisol — a hormone that helps regulate stress, metabolism, and immune function. Excessive cortisol can lead to a range of symptoms, many of which develop gradually and are easy to overlook in the early stages.

Here are some common signs to watch for:

  • Increased thirst and urination
  • Excessive hunger
  • Hair loss or thinning coat
  • Pot-bellied appearance
  • Skin issues, such as thinning or darkening
  • Lethargy or reduced activity levels
  • Frequent panting
  • Muscle weakness

If your dog is showing one or more of these symptoms, it doesn’t automatically mean they have Cushing’s disease, but it’s worth discussing your concerns with your vet. Early diagnosis can make a significant difference in managing this condition effectively.

🔍 Possible Causes

There are two primary types of Cushing’s disease in dogs, each with different underlying causes:

  • Pituitary-Dependent Cushing’s: This is the most common form, accounting for approximately 80–85% of cases. It occurs when a benign tumor in the pituitary gland stimulates excessive cortisol production.
  • Adrenal-Dependent Cushing’s: In this less common form, a tumor on one of the adrenal glands causes the overproduction of cortisol.

In rare cases, long-term use of corticosteroid medications prescribed for other medical conditions can lead to a condition known as iatrogenic Cushing’s disease. While this form is not caused by the body itself, it mimics the symptoms of naturally occurring Cushing’s and requires careful management.

✅ What You Can Do at Home

While you can’t prevent Cushing’s disease entirely, there are steps you can take to support your dog’s overall health and well-being:

  • Feed your dog a balanced, nutritious diet tailored to their age and size.
  • Maintain a healthy weight to reduce strain on their body.
  • Provide regular exercise appropriate for your dog’s breed and energy levels.
  • Monitor your dog for changes in behavior, appetite, or appearance, and keep track of any concerns to share with your vet.

It’s also important to minimize stress in your dog’s environment, as stress can exacerbate symptoms of Cushing’s disease. Keeping a consistent routine, offering plenty of mental stimulation, and ensuring your dog feels safe and secure at home can all make a big difference.

💡 When to Call a Vet

If you suspect your dog may have Cushing’s disease, consulting your veterinarian is essential. Diagnosis typically involves a combination of physical exams, blood tests, and specialized tests like the ACTH stimulation test or low-dose dexamethasone suppression test. Imaging, such as ultrasound, may also be used to identify adrenal tumors.

Once diagnosed, your vet will discuss treatment options tailored to your dog’s specific needs. These may include:

  • Medication: Drugs like trilostane or mitotane are commonly prescribed to manage cortisol levels.
  • Surgery: In cases of adrenal tumors, surgical removal may be recommended.
  • Monitoring: Regular follow-up appointments and blood tests are crucial to ensure your dog’s treatment is effective and well-tolerated.

Left untreated, Cushing’s disease can lead to complications such as diabetes, high blood pressure, or kidney damage. Early intervention and proper management can significantly improve your dog’s quality of life and help them enjoy their golden years to the fullest.

FAQs

Q: Can Cushing’s disease be cured?
A: While pituitary-dependent Cushing’s cannot be cured, it can be managed effectively with medication and regular monitoring. Adrenal-dependent Cushing’s caused by a tumor may be curable through surgery in some cases.

Q: How long can a dog live with Cushing’s disease?
A: With appropriate treatment and care, many dogs with Cushing’s disease can live a happy and comfortable life for several years after diagnosis.

Q: Is Cushing’s disease painful for dogs?
A: The condition itself is not typically painful, but the symptoms and complications can affect your dog’s comfort. Prompt treatment can help alleviate these issues.

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References

While every effort is made to ensure the accuracy of this content - including vet review where applicable - this article is for informational purposes only and is not a substitute for professional veterinary advice, diagnosis, or treatment. If your pet is unwell or you are concerned, please speak with a licensed veterinarian. You can book a $49 online consultation with our veterinary team  😄
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